Ep. 95 Polygenic Risk Scoring: An Epidemiologist’s Perspective

A. Cecile Janssens, PhD

Has cardiovascular genetics come of age? Are “polygenic risk scores” ready to inform us in clinically meaningful ways? In the final analysis, who or what are epidemiological data informing? Our guest is A. Cecile Janssens, PhD, Professor of Translational Epidemiology at the Rollins school of Public Health at Emory university in Atlanta, GA.

Professor Janssens’ research concerns the translation of genomics research to applications in clinical and public health practice and focuses on the genetic prediction of common diseases such as diabetes, cardiovascular disease and cancer. She also studies how the predictive ability and utility of genetic testing can best be measured.


A. Cecile Janssens, PhD:  Twitter and website


The following graphs referred to on the podcast are taken from the paper by Torkamani, Wineinger, and Topol: The personal and clinical utility of polygenic risk scores.












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