Ep. 182 Approving COVID Vaccines for Children: Part 1 with Paul Offit

Our guest is Dr. Paul Offit, an expert on vaccines, immunology, and virology. He is the Maurice R. Hilleman Professor of Vaccinology, Professor of Pediatrics at the Perelman School of Medicine at the University of Pennsylvania and Director of the Vaccine Education Center at The Children’s Hospital of Philadelphia. He is also a member of the FDA’s Vaccines and Related Biologic Products Advisory Committee (VRBPAC) which recently approved the EUA for the Pfizer’s Covid-19 vaccine for children age 5-11.

This is part 1 of a 2-part series on this topic.


Paul Offit, MD: Twitter and Webpage


Watch the episode on our YouTube channel


  1. Paul Slobodian on 11/15/2021 at 2:33 AM

    Excellent. I think you alluded to it but didn’t get a clear answer: might there be other side effects of mrna vaccines that haven’t yet been identified due to the relatively small n of the studies (thinking of healthy young)? And based on the hx of vaccines, have we ever discovered negatives of a vaccine after it was approved?

    • Michel Accad on 11/15/2021 at 4:24 AM

      Thank you, Paul. If I recall correctly Dr. Offit did comment that you can never have absolute certainty. There certainly have been historical examples of vaccines that were found to have serious side-effects after they were released. Two that come to mind are the original Rotavirus vaccine that was found to occasionally cause intussusception (bowel obstruction) which led to its recall. Also, the Dengue vaccine is known to make recipients susceptible to antibody-dependent enhancement (ADE), which means that in on rare occasion, a vaccinated person can contract the virus and get a more severe illness than if they had not been vaccinated. MA.

  2. Bob Perillo on 11/15/2021 at 11:58 PM

    Why no mention of inadvertent IV injection? I find it absolutely amazing that they can hold an almost hour-long discussion without braoching the subject.

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