Ep. 100 Can We Trust Generic Drugs? The Ranbaxy Whistleblower Narrates the Pharma Scandal of the Century

Dinesh Thakur

Generic drugs represent 90% of the pharmaceutical market. Their use has been encouraged through decades of favorable legislation and subsidies, with authorities claiming they are as safe and effective as brand name drugs. Yet generic preparations tainted with impurities are being reported with increasing frequency. What should doctors and the public know about generic drug manufacture? Our guest is the chemist who was at the center of the most important scandal to rock the global pharmaceutical industry in decades.


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  1. Paul Slobodian on 11/28/2019 at 5:26 PM

    Perhaps a dumb question re efficacy/equivalence of generics:
    Vs extensive patient testing in patients and validation of development data…is is not possible to just do a chemical analysis of name brand pill x and compare it to the generic pill x and see if it is the same?

    • Michel Accad on 11/28/2019 at 7:39 PM

      You can. I think the main issues with efficacy of generics is whether the amount of drug is reliably what it’s supposed to be (with acceptable parameters of variation) and whether the formulation (filler, encapsulation, slow release mechanism, or whatever) leads to the appropriate drug levels in the body as intended. You could not check the latter by chemical analysis.

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